
There are 15 workpackages within EuroCoord summarised below.
Click on the diagram to find out more:
Lead beneficiary: UCL
The Management WP will ensure optimal scientific and infrastructure synergy over the day-to-day operations and facilitate cross-network communication. The long-term goal is to continue to guide and coordinate scientific methodologies that have previously been so successful in Europe and to ensure that new competitive science areas are encouraged and supported.
The MRC Clinical Trials Unit at UCL will be leading this effort in close collaboration with the UCL European Research and Development Office (ERDO) which will provide specific expertise on contractual, financial, and administrative matters as part of the project management of the network.
Lead beneficiary: PENTA
The main objectives of this WP are to improve research skills including statistical techniques to allow researchers to undertake observational research of the highest calibre, and to provide basic and updated laboratory and clinical training to aid the management of HIV-infected patients. This will be achieved through a variety of ways including: online resources, residential courses, PhD, and short term staff exchanges.
A further key task of this WP is the organisation of the annual International Workshop on HIV Observational Databases (IWHOD). The objective of this highly successful workshop is to bring together researchers from both developed and developing countries working on cohorts of patients with HIV, to present in an informal, closed-meeting format new research and allow open discussions on common issues of cohort methodology, techniques and statistics. Read more about IWHOD.
This work will build on the successes of ACTIVATE.
The WP2 working group is made up of representatives from the 4 founding networks and include members with experience of coordinating EU-funded training programmes.
The leader of the group will rotate between the WP network representatives every 15 months to fully utilise the expertise within the whole EuroCoord network.
Lead beneficiary: UCL
The Scientific Oversight WP will serve to maintain overall coherence of EuroCoord scientific activities and will lead the overall advancement of the scientific research agenda. The Scientific Oversight WP Group (SOG) will be responsible for a centralised review of the ongoing research in each key area as well as each founding network.
With the help of specialist subgroups in specific defined areas of importance (statistical methodology, hepatitis, pharmacokinetics, and virology), the SOG will oversee progress, identify potential overlap and suggest areas of collaboration. The members of the SOG and four specialist subgroups represent a range of high-level scientific expertise.
The Scientific Coordinator will rotate between the WP network representatives every 15 months to fully utilise the expertise within the whole EuroCoord network.
Lead | Member | |
---|---|---|
Scientific Oversight | Dominique Costagliola (Until December 2015) | Caroline Sabin, University College London (CASCADE) |
Dominique Costagliola, Institut National de la Santé et de la Recherche Médicale (COHERE) | ||
Peter Reiss, Academic Medical Centre University of Amsterdam (EuroSIDA) | ||
Dominique Costagliola (INSERM) | ||
Additional Members to Scientific Oversight | Jose Gatell - University of Barcelona | |
Gerd Fätkenheuer- University of Köln | ||
Irja Lutsar -Institute of microbiology, University of Tartu | ||
Alex Compagnucci - Institut National de la Santé et de la Recherche Médicale (INSERM) | ||
Methodology Group | Giota Touloumi | Giota Touloumi, Kapodistrian University of Athens (CASCADE) |
Daniel Grint, University College London (EuroSIDA) | ||
Rodolphe Thiebaut, Université Victor Segalen Bordeaux 2 (CASCADE, EuroSIDA) | ||
Jonathan Sterne, Univeristy of Bristol (COHERE) | ||
Dominique Costagliola, Institut National de la Santé et de la Recherche Médicale (COHERE) | ||
Alessandro Cozzi-Lepri, University College London (EuroSIDA) | ||
David Dunn, MRC Clinical Trials Unit at UCL (PENTA) | ||
Hepatitis Group | Claire Thorne | Claire Thorne, Institute of Child Health at UCL (PENTA) |
François Dabis University Bordeaux Segalen (COHERE) | ||
Maria Prins, Public Health Service of Amsterdam (CASCADE) | ||
Roberto Muga, Generalitat de Catalonia (CASCADE) | ||
Antonella d’Arminio Montforte, Università degli studi di Milano (COHERE) | ||
Jϋrgen Rockstroh, Universitätsklinikum Bonn (EuroSIDA) | ||
Amanda Mocroft, University College London (EuroSIDA) | ||
Jose Tomas Ramos Amador, Portal de Salud de la Comunidad de Madrid (PENTA) | ||
Virology Group | Roger Paredes | Marie-Laure Chaix, Université Paris Descartes (CASCADE) |
Claudia Kϋcherer, Robert Koch-Institut (CASCADE) | ||
Dimitrios Paraskevis (COHERE) | ||
Huldrych Gunthard, Universitäts Spiral Zürich (COHERE) | ||
Roger Paredes, Investigadors de l'Institut de Recerca de la Sida (EuroSIDA) | ||
Alessandro Cozzi-Lepri, University College London (EuroSIDA) | ||
Anita deRossi, Università deglii Studi di Padova (PENTA) | ||
Kids to adults group | Ali Judd | Julia del Amo, Instituto de Salud Carlos III (CASCADE) |
Ali Judd, MRC Clinical Trials Unit at UCL (PENTA) | ||
Claire Thorne, University College London (PENTA) | ||
Anne-Franҫoise Gennotte, St-Pierre University Hospital (EuroSIDA) | ||
David Nadal, University of Zurich (EuroSIDA) | ||
Caroline Sabin, University College London (CASCADE, COHERE) | ||
Pablo Rojo Conejo, Hospital 12 de Octubre (COHERE) | ||
Monitoring group | Yazdan Yazdanpanah | Jeannie Collins, MRC Clinical Trials Unit at UCL (PENTA) |
Heiner Bucher,University Hospital Basel(CASCADE) | ||
Caroline Sabin, University College London (CASCADE, COHERE) | ||
Yazdan Yazdanpanah, Institut National de la Santé et de la Recherche Médicale (COHERE) | ||
Antonella d'Arminio Montforte, Università degli studi di Milano (EuroSIDA) | ||
Amanda Mocroft, University College London (EuroSIDA) | ||
Nina Friis-Møller, Copenhagen University, CHIP (COHERE) | ||
Colette Smitt, HIV Monitoring Foundation (COHERE) |
Lead beneficiary: UZH
The objective of the Data Management WP is to ensure harmonisation of data variables captured by the networks with the aim of ensuring that cross-network data mergers of specified variables can readily occur.
Additionally, the WP will coordinate cross-network data mergers for scientific projects where two or more networks have agreed to collaborate. This WP will provide an inventory (on an annual basis) of data and biological material contained within each network to the Executive Board for inclusion in the annual report.
The leader of the group will rotate between the WP network representatives every 15 months to fully utilise the expertise within the whole EuroCoord network.
Each network and each new science WP has its internal data manager structure represented within this WP. Cross-network communication will occur at least quarterly.
Lead beneficiary: PENTA
WPs 5 & 6 are PENTA-specific. The broad aims are to:
Lead beneficiaries: UCL & INSERM
WPs 7 & 8 are CASCADE-specific. The aims are to provide the framework within which to conduct and analyse data from HIV seroconverters by:
The WPs also aim to characterise newly-acquired HIV infection, its contribution to the epidemic, and to assess outcome and its determinants in individuals with early diagnosis, focussing on:
Lead beneficiary: Region Hovedstaden (RegionH)
WPs 9 & 10 are EuroSIDA-specific. The objectives can be broadly classified as:
Further task include:
Lead beneficiaries: UB2 & RegionH
WPs 10 & 11 are COHERE-specific. The WPs aim to coordinate, administer and oversee research projects for COHERE generated by its cohorts, project and theme leads, in order to increase the knowledge on HIV clinical epidemiology that require very large observational databases.
These projects focus on:
Response to cART
Characterising history of HCV and HIV infection among co-infected patient
Epidemiology of rare or specific conditions.
Lead beneficiary: RegionH
The objectives of this prospective joint activity on TB and HIV coinfection are to:
Lead beneficiary: ISCIII
This WP aims to prevent HIV infection, and improve diagnosis and prognosis of migrant populations living with HIV in Europe by providing evidence to support policy development at European level. It also aims to determine the likely country of HIV acquisition for migrant populations and identify barriers to HIV prevention, testing, and treatment.
Key outcomes and their determinants will be studied by geographical origin and sex:
with the previous HIV-related outcomes.
Lead beneficiary: UCL
The broad aim of this WP is to build a stochastic computer simulation model of HIV infection and the effect of ART and to fit the model to data from European countries in order to estimate the status of HIV infected populations across Europe, in terms of diagnosis, treatment usage, resistance, pregnancy, and rates of AIDS and death.
A European HIV Estimates Working Group will be established with the following aims: